Profile of Brian K. Kobilka and Robert J. Lefkowitz, 2012 Nobel Laureates in Chemistry
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Profile of Brian K. Kobilka and Robert J. Lefkowitz, 2012 Nobel laureates in chemistry.
Those of us that had been hammering away in the field for 40 years or more cannot deny the excitement in learning that Brian Kobilka, a former postdoctoral fellow of Robert Lefkowitz, in collaboration with Roger Sunahara, had determined the structure of the agonist-bound β2-adrenergic receptor-Gs protein complex (1). To borrow a phrase from Henry Bourne, this is “the Big Enchilada” for the G pr...
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The 2012 Nobel Prize in Chemistry has been awarded to Brian K. Kobilka and Robert J. Lefkowitz for their studies of G-protein-coupled receptors. Their pioneering work over the past 40 years has provided detailed molecular insight into the structure and function of this fundamentally important family of receptors.
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Mankind has long been fascinated by the discovery and invention of new technologies and gadgetry. Often times this fascination is borne out of necessity, but in many other cases, the sometimes lifelong pursuit is that of pure intellectual curiosity. The beginning of the 19th century revealed as much when Alessandro Volta reported (1) the first electrical battery—now referred to as a Voltaic cel...
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As a postdoctoral student at the Massachusetts Institute of Technology in 1978, I trolled the literature, seeking inspiration for my career as an experimental physicist. One article that caught my attention described the first laser-cooling experiment. David Wineland et al. at the National Bureau of Standards (NBS, now the National Institute of Standards and Technology) in Boulder, CO, had trap...
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You can read the Nobel Prize Web site for the best description of the science behind the 2013 Nobel Prize in Chemistry. However, let me tell you what the beginnings of the science and its immediate impact were really like–a personal account from a close bystander and indirect collaborator in a neighboring field who grew up scientifically with two of the laureates, and knows well the third. The ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2013
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1221820110